As product of a highly collaborative effort in the International Inflammatory Bowel Disease Consortium, “Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility” is now published in Nature Genetics. We directly implicated ten genes that elevate or lower a person’s risk of Crohn’s disease, a form of inflammatory bowel disease. Six of those […]

NIDDK has awarded the Huang Lab a 5-year R01 grant to identify and characterize causal variants underlying inflammatory bowel diseases (IBD). Through a collaboration with the Marson lab, we will identify putative causal variants for IBD through harmonizing and fine-mapping large-scale genomic resources across multiple ancestries, and characterize their molecular and cellular impacts through targeted genome perturbations […]

In collaboration with the Ge lab,  “Improving Polygenic Prediction in Ancestrally Diverse Populations” is now published in Nature Genetics. PRS-CSx is a novel PRS construction method which improves cross-population polygenic prediction by integrating GWAS summary statistics from multiple populations. PRS-CSx code is openly available at GitHub