“Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility” published in Nature Genetics.

As product of a highly collaborative effort in the International Inflammatory Bowel Disease Consortium, “Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility” is now published in Nature Genetics.

We directly implicated ten genes that elevate or lower a person’s risk of Crohn’s disease, a form of inflammatory bowel disease. Six of those genes had no previous links to the disorder, and four are in regions of the genome that other studies had linked to Crohn’s disease.

Huang lab is awarded NIH R01 funding to carry out a genetics study of bipolar disorder in East and South Asia

NIMH has awarded Huang Lab a 5-year R01 grant to carry out a genetics study of bipolar disorder in East and South Asia. This is one of the four collaborative grants awarded to the Asian Bipolar Genetics Network (A-BIG-NET), including Huang lab, Kendler lab, Zandi lab, and Kuo lab. Working with leading investigators from East and South Asia, A-BIG-NET will establish a valuable genetic resource of 27,500 bipolar I cases and 16,000 controls, all with sequencing data, rich phenotypic information, and measures of key environmental stressors. A-BIG-NET will dramatically increase the worldwide diversity of genetics data on bipolar disorder, an important step to accelerate gene discovery in this disorder and advance global mental health equity.

 

Huang lab is awarded NIH R01 funding to study the genetics of inflammatory bowel diseases

NIDDK has awarded the Huang Lab a 5-year R01 grant to identify and characterize causal variants underlying inflammatory bowel diseases (IBD). Through a collaboration with the Marson lab, we will identify putative causal variants for IBD through harmonizing and fine-mapping large-scale genomic resources across multiple ancestries, and characterize their molecular and cellular impacts through targeted genome perturbations and knockins in human T cells. We hope the new IBD causal variants and biology from this study will provide new insights into IBD pathogenesis, make an important positive impact and serve as the fundamental resource and basis for novel IBD therapeutics.

“Improving Polygenic Prediction in Ancestrally Diverse Populations” published in Nature Genetics.

In collaboration with the Ge lab,  “Improving Polygenic Prediction in Ancestrally Diverse Populations” is now published in Nature Genetics.

PRS-CSx is a novel PRS construction method which improves cross-population polygenic prediction by integrating GWAS summary statistics from multiple populations. PRS-CSx code is openly available at GitHub

 

Yu Chen joined Huang Lab as a visiting graduate student

Yu Chen joined Huang Lab as a visiting graduate student on October 25, 2021. Yu is a Ph.D. candidate with Dr. Chao Chen at Central South University.

Yu Chen received the ASHG/Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research – Semi-Finalists

Yu Chen received the ASHG/Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research – Semi-Finalists

Kai Yuan received the ASHG/Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research – Semi-Finalists

Kai Yuan received the ASHG/Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research – Semi-Finalists

Ruize Liu received the ASHG/Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research – Semi-Finalists

Ruize Liu received the ASHG/Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research – Semi-Finalists

Mingrui Yu joined Huang Lab as a Computational Associate I

Mingrui Yu joined Huang Lab as a Computational Associate on August 16, 2021. Mingrui received his Bachelor of Science degree from University of California Santa Cruz in 2021.