Huang lab is awarded NIH R01 funding to study the genetics of inflammatory bowel diseases

NIDDK has awarded the Huang Lab a 5-year R01 grant to identify and characterize causal variants underlying inflammatory bowel diseases (IBD). Through a collaboration with the Marson lab, we will identify putative causal variants for IBD through harmonizing and fine-mapping large-scale genomic resources across multiple ancestries, and characterize their molecular and cellular impacts through targeted genome perturbations and knockins in human T cells. We hope the new IBD causal variants and biology from this study will provide new insights into IBD pathogenesis, make an important positive impact and serve as the fundamental resource and basis for novel IBD therapeutics.