In collaboration with Dr. Dermot McGovern’s team, Ruize Liu, Hailiang Huang and others published “Profiling the inflammatory bowel diseases using genetics, serum biomarkers, and smoking information” in iScience.
Inflammatory bowel diseases (IBDs) are globally prevalent and heavily influenced by genetics, but the majority of genetic data collected about them have come from people of European ancestry. We performed the largest IBD genetics study to date in East Asian populations. We revealed 80 new IBD-associated genetic loci just in people from East Asia, and 320 loci when analyzed together with data from European individuals. We also constructed a new, more accurate polygenic score for IBD risk.