Working with collaborators from FinnGen, IIBDGC and various East Asian countries, we published “Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries” in Nature Genetics.
Inflammatory bowel diseases (IBDs) are globally prevalent and heavily influenced by genetics, but the majority of genetic data collected about them have come from people of European ancestry. We performed the largest IBD genetics study to date in East Asian populations. We revealed 80 new IBD-associated genetic loci just in people from East Asia, and 320 loci when analyzed together with data from European individuals. We also constructed a new, more accurate polygenic score for IBD risk.