The Huang lab leads and contributes to inflammatory bowel diseases (IBD) genetics studies through collaborations with the international IBD genetics consortium (IIBDGC), the Daly Lab, the Xavier Lab and as a member of the Center for the Study of IBD at the Massachusetts General Hospital. Dr. Huang led the IIBDGC fine-mapping project which developed a novel fine-mapping method and applied it on ~ 70,000 European samples. This effort mapped 45 IBD associations to single variants with over 50% casual probabilities, significantly advancing our knowledge in IBD genetics (Huang et. al., Nature 2017). Following this study, the Huang lab focuses on understanding the tissue-specific gene regulations in the non-coding genome and their connections with IBD genetics, studies combining exome-sequencing and fine-mapping to reveal the genetic basis of IBD across the full allelic spectrum, and studies to understand the IBD genetic architecture cross major world populations.